The treatment of pediatric HIV disease, especially of newborn children and youthful youngsters, remains perplexing and hazardous. The fast development and organ framework development and enthusiastic furthermore, subjective changes that happen over the formative range from early stages through puberty muddle tranquilize improvement and organization. Adherence results in kids have been not exactly powerful and emotional wellness and conduct issues are rising as basic to comprehend and address so as to guarantee the achievement of long haul treatment. Also, while less tainted kids are being conceived, there are expanding worries about the long haul effect of in utero and postnatal exposures to antiretroviral drugs for those kids who departure HIV. As of now an expected 20% of all newborn children conceived in sub-Saharan Africa are uncovered to HIV and antiretrovirals during pregnancy and the postnatal period.